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Special Semester on Quantitative Biology analyzed by Mathematical Methods
Linz, October 1, 2007 - January 27, 2008
A Threestepped Coordinated Level Set Segmentation Method for Extracting Atherosclerotic Plaques from MR-Images

Workshop on Bioimaging II / PDEs, Tue, 20 Nov, 2007

Speaker: Oliver Gloger

Abstract

In this work we propose an adapted level set segmentation technique for the recognition of atherosclerotic plaque tissue on magnetic resonance images. We extended a method for the curvature based anisotropic diffusion and applied it to denoise magnetic resonance images from plaques. The denoised images serve as an appropriate basis for the application of our level set segmentation technique.
The segmentation technique is subdivided into three steps whereas the result of every phase serves as prior knowledge for the next step. By analyzing and combining carefully all available channel information during the first and second step we are capable to border the vessel walls on the images. For achieving local exact segmentation results we support the plaque detection with so-called Canny edges.
The third step controls an enclosing level set which circumvents the plaque patterns from healthy media tissue. In this step we introduce a local weighting concept for intensity information of plaque patterns. Furthermore, we justify the introduction of a maximal shrinking distance for the third level set and show very promising results of this method in special figures during the level set propagation.
The extension of the level set segmentation with locally weighted intensity information and a maximal shrinking distance allows the algorithm to automatically distinguish plaque from healthy media tissue. Furthermore, we are capable to detect and segment plaque patterns which are complicated to recognize for the human observer.

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