Workshop on Biomechanics and Chemotaxis, Tue, 11 Dec, 2007
Speaker: Anita Kettemann
Abstract
In metastatic tumors, cells detach from the primary tumor and invade neighbouring tissue in order to enter a blood vessel. That way, they can reach distant organs, start to proliferate again and build secondary tumors. During the tissue invasion the movement of the cells can be supported or constrained by the structure of the tissue network. Besides, the cells can remodel the network by mechanical and chemical processes. There is some experimental evidence, that chemosensitivity as well plays an important role in metastasis.
In this talk, I will present a macroscopic model that comprises the complex interactions of cells and tissue as well as the chemosensitive cell dynamics during the invasion process. The local existence and uniqueness of a weak solution for a simplified version of the model will be shown.
URL: www.ricam.oeaw.ac.at/specsem/ssqbm/participants/abstracts/index.php
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