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Special Semester on Quantitative Biology analyzed by Mathematical Methods
Linz, October 1, 2007 - January 27, 2008
Mathematical Models of Cell Cycle Regulatory Networks

Workshop on Systems Biology, Mon, 05 Nov, 2007

Speaker: Attila Csikasz-Nagy

Abstract

A very well characterized biological network is the cell cycle regulatory system of yeasts. We know more and more of the same system in mammals as well. I have been developing mathematical models of these regulatory systems in different organisms. I will present how we construct these models, what tools we use for their analysis. I will elucidate how the models explain dynamical transitions of the cell cycle and how it can predict experimentally testable features of the network. It will be presented how feedback signals in the regulatory network makes these transitions irreversible; correcting the biological text book view that protein degradation is responsible for irreversible cell cycle transitions.

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