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Special Semester on Quantitative Biology analyzed by Mathematical Methods
Linz, October 1, 2007 - January 27, 2008
THE ROLE OF FLUID-STRUCTURE INTERACTION FOR MEDICAL DEVICE DESIGN

Workshop on Biomechanics and Chemotaxis, Fri, 14 Dec, 2007

Speaker: Pascal Verdonck

Abstract

Computer-based numerical flow and mass transport simulation tools, such as Computational Fluid Dynamics (CFD), can provide detailed, three-dimensional predictions of fluid flow and mass transport in complex geometries. Commercially available, general purpose CFD software is now routinely used as a design tool in the aerospace, automotive and process industries, and has also been applied to predict the flows and mass transfer in various medical devices. Computational fluid dynamics CFD has begun to alter the development process of artificial organs and is now a major issue on international artificial organs congresses CFD techniques and principles are applicable and valuable in the development of any blood contacting medical device with demanding performance and reliability requirements. Used at appropriate stages of the design cycle, ideally integrated with other computational tools such as finite-element analysis (FEA) , CFD offers a detailed understanding of fluid mechanics which complements the clinical, technical and experimental experience of the design team.

A major benefit offered is the ability to evaluate at early stage designs quickly, before committing to the expense of prototype manufacture and testing. When applied with sound engineering judgement, CFD and FEA can therefore reduce the costs, timescales and risks associated with development of a new design. At the detailed design stage, CFD can quickly investigate the effects of design changes on blood flow, to reduce the risk of unexpected knock-on effects which otherwise would only become apparent at a later stage. When a final design has been reached, CFD analysis can be used to confirm that design goals have been achieved. The detailed CFD picture of the flow field can often be used to support and explain experimental results, potentially strengthening regulatory submissions and providing a scientific base for clinical use.

Computational assessment, including fluid-structure interaction (FSI) in the design phase of an artificial organs decreases the effort and cost of design and aids development as clearly will be shown for the design of rotary blood pumps, heart valves, bioreactors, stents.

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