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Special Semester on Quantitative Biology analyzed by Mathematical Methods
Linz, October 1, 2007 - January 27, 2008
On the Inverse Problem for a Size Structured Model

Workshop on Biomechanics and Chemotaxis, Wed, 12 Dec, 2007

Speaker: Jorge Zubelli

Abstract

We consider a size-structured model for cell division and address the question of determining the division (birth) rate from the measured stable size distribution of the population. We formulate such question as an inverse problem for an integro-differential equation posed on the half line. We develop firstly a regular dependency theory for the solution in terms of the coefficients and, secondly, a regularization technique for tackling this inverse problem which takes into account the specific nature of the equation.
Our results rely also on generalized relative entropy estimates and related Poincare inequalities.
This is joint work with Benoit Perthame (ENS).

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