Workshop on Pattern Formation and Functional Morphology, Thu, 10 Jan, 2008
Speaker: Peter Waterhouse
Abstract
Over the last few years, it has become increasingly apparent that a number of key processes in plants and animals are regulated by small RNAs (21-24 nucleotides in length). In plants, the roles of such RNAs include: regulation of developmental transitions, directing responses to environment, and defending against virus infection. These roles are mediated by targeted RNA degradation resulting in gene silencing. In addition, small RNAs affect the expression of genes by directing chromatin modifications and shutting-down transposon activity. All of the pathways share some common components and probably act as a complex inter-connecting network. Some of these plant pathways are mirrored in animals, but the ability to generate a mobile signal that induces gene silencing appears to be unique to plants.
To more fully understand the interactions of these networks, new experimental and mathematical protocols are being explored and developed. Recent experiments tracking the movement of a gene silencing signal and measuring the levels of the gene silencing components, are giving insights into the underlying dynamics and interactions.
URL: www.ricam.oeaw.ac.at/specsem/ssqbm/participants/abstracts/index.php
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