Special Semester on Quantitative Biology analyzed by Mathematical Methods
Linz, October 1, 2007 - January 27, 2008
Events: Workshop on
Ion Channels|Systems Biology|Bioimaging I|Bioimaging II/PDEs|Biomechanics and Chemotaxis|Pattern Formation and Functional Morphology
Workshop on Ion Channels, October 8-12, 2007


Martin Burger, University of Münster, Germany
Robert Eisenberg, Rush University and Argonne National Laboratory, Chicago IL, USA
Heinz W. Engl, RICAM & Johannes Kepler University Linz, Austria
Peter Pohl, Johannes Kepler University Linz, Austria

Workshop Abstract

Channels control the flow of many substances into and out of cells and are of enormous importance in health and disease. Channels and transporters make up a large fraction of all the proteins in the human body and are studied experimentally by thousands of molecular biologists. Many of the drugs used by physicians act on channels, and their structure is known with atomic resolution. Ion channels work by switching between open and closed states. In the open state, they have a structure that does not change significantly on a time scale relevant for simulations. Ions move through the open channel by electrodiffusion controlled by the density of permanent and polarization charge on the channel protein, and the shape of the hole in the channel. The driving forces for ion movement are concentration gradients and the electrical potential across the channel protein. The movement of ions through the channel can be described by the Poisson-Nernst-Planck equations. Selectivity of membrane channels is, in part, achieved by size exclusion, in particular in water channels. In the limiting case, pores are so narrow that water molecules and ions cannot pass each other. So far little is known about water mobility in confined pores, and it is an important task to obtain further insight by quantitative mathematical models and simulations.

Confirmed Speakers

Kattrin Arning, RICAM, Austria
Jaydeep Bardhan, Argonne National Laboratory, USA
Dezso Boda, Rush University Medical Center, USA
Steve Cox, Rice University, USA
Robert Eisenberg, Rush University and Argonne National Laboratory, USA
Dirk Gillespie, Rush Medical University, USA
Clemens Heitzinger, TU Wien, Austria
Douglas Henderson, Brigham Young University, USA
Peter Hinterdorfer, Johannes Kepler University Linz, Austria
Gerhard Hummer, National Institutes of Health, USA
Dmitry Karpeev, Argonne National Laboratory, USA
Gernot Kieseritzky, Free University Berlin, Germany
Ernst-Walter Knapp, Free University Berlin, Germany
Matthew Knepley, Argonne National Laboratory, USA
John Lowengrub, University of California, USA
Maria Neuss-Radu, University of Heidelberg, Germany
Wolfgang Nonner, University of Miami, USA
Peter Pohl, Johannes Kepler University Linz, Austria
Roland Roth, Max Planck Institute for Metals Research, Germany
Zuzanna Siwy, University of California, USA
Thomas Weikl, Max Planck Institute of Colloids and Interfaces, Germany
Marie-Therese Wolfram, Universitaet Muenster & RICAM, Germany

Time Schedule Workshop on Ion Channels

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