The 15th International Conference on Monte Carlo and Quasi-Monte Carlo Methods in Scientific Computing (MCQMC 2022) was hosted by the Johannes Kepler University (JKU) and the Johann Radon Institute for Computational and Applied Mathematics (RICAM), in Linz, Austria, in July 2022. Both JKU and RICAM are hosting institutions of the Special Research Program "Quasi-Monte Carlo Methods: Theory and Applications" funded by the Austrian Science Fund, FWF.